Blood cancer genetic link
Do we know enough about the genetic involvement in laryngeal cancer susceptibility and prognostic outcome? Corina Iulia Cornean, Marcel Cosgarea, Andreea Catana, Carmen Aurelia Mogoanta, Violeta Necula, Alma Aurelia Maniu Introduction: Advances in molecular biology have opened the door to a wide range of research material through the usage of genetic testing on certain variables within the human genome known as single-nucleotide polymorphisms SNPs.
The purpose of this article is to present a review on the influence variants within SNPs have on the outcome of laryngeal cancer when associated with different variables, such as external toxins or survival rate. Amongst these toxins, the most frequent and most studied have been alcohol and tobacco consumption, with a proven increased rate of overall cancer risk within the aero-digestive tract. Materials and Methods: The review was realized utilizing available studies on the subject of genetic polymorphisms analysis of deoxyribonucleic acid DNA samples using polymerase chain reaction PCR assays and laryngeal cancer published in the PubMed database.
Results: Statistical analysis of polymorphisms shows a predominantly positive association between two genetic variants of the human genome mutant homozygote and heterozygote and cancer risk with significant influence on patient outcome and survival. Genotype combinations were divided into two categories depending on the individual at risk and protective allele within the loci of each inherited gene block. Amongst the genes involved with aero-digestive cancers, the most studied were those belonging to the xenobiotic metabolism, nucleotide excision repair NER and DNA repair pathways.
The presence of toxins has a distinct cumulative effect within the genotype-phenotype relationship, which further influences the presence of malignancy depending on the adaptability of each individual genome.
Conclusions: Laryngeal cancer evolution is linked to inherited risk factors found within the genetic code. Most studied were the genes belonging to NER pathways, DNA repair and blood cancer genetic link metabolism, which all favored mutant homozygote and heterozygote variants, as high risk factors.
Only five articles focused on overall survival rates with insufficient results to undisputedly predict the risk variants. The consumption of external toxins has a positive effect on the overall cancer risk in consumers. Most articles affirmed further evaluation or replication was needed in a larger scale population to conclusively validate their results.
PDF 2. The heritable MTC results from a germline mutation in the rearranged during transfection RET proto-oncogene and is included into the multiple endocrine neoplasia 2 MEN2being associated with other endocrine abnormalities and clinical features.
MTC is a neuroendocrine tumor that releases a wide range of secretory products that are responsible for a variety of symptoms, making it difficult to be diagnosed. For this reason, the pathological analysis is of vital importance to ensure that the versuri myparasites diagnosis is made. This review presents the main data from the contemporary literature related blood cancer genetic link the pathological diagnosis of a patient with MTC and highlights the wide range of tumor cytological features, the many histological variants, as well as the particular tumor immunophenotype.
Antiplatelet therapy in secondary ischemic stroke prevention - a short review Cristina Florescu, Edme Roxana Mustafa, Elena-Anca Tartea, Diana-Ruxandra Florescu, Valeria-Carmen Albu Platelets play an essential role in atherothrombosis and for this reason they are the primary target of antithrombotic therapy in ischemic stroke. We discussed here paraziti lidskeho tela evidence for efficacy and safety of current knowledge in antiplatelet therapy for stroke prevention after an acute ischemic stroke or transient ischemic attack.
After an acute episode, long-term antithrombotic therapy is essential for the secondary prevention of stroke recurrence and complications. These are aspirin, clopidogrel and dipyridamole. All of these antiplatelet therapies, besides inhibiting acute arterial thrombosis, also interfere with physiological hemostasis.
In conclusion, we can say that current recommendations focused primarily on the therapy with aspirin for the secondary prevention of stroke in patients that presented vascular events, such as ischemic stroke of non-cardioembolic cause or transient ischemic attack and, as appropriate, aspirin plus dipyridamol blood cancer genetic link clopidogrel.
The new therapy with ticagrelor in secondary stroke prevention seems to be promising, but more randomized clinical trials are needed to accurately blood cancer genetic link the safety and efficacy of this new antiplatelet drug. Current understanding of psycho-neurobiology in depressive disorders with suicidal thoughts - translational models Eduard Nicusor Bondoc, Dragos Marinescu, Ileana Marinescu, Ramona Denise Malin, Liliana Stanca, Roxana Eugenia Zavoi Epidemiological data confirm the rising incidence of depression associated with suicidal ideation and cardiovascular comorbidities of coronary type.
In contradiction with the large number of antidepressant drugs, the therapeutic results are not satisfactory, with numerous existing incomplete remissions characterized by maintained cellular dysfunctionalities that amplify the oxiuros tratamiento y prevencion deterioration and the risk of several somatic comorbidities.
The surprising fact is the relatively high number of deaths in this type of patients due to acute coronary disease myocardial infarction - MI. The vulnerability of hippocampal and frontal cortex cerebral structures is presented as obtained on animal model consecutive to hypothalamic-pituitary-adrenal HPA axis hyperactivity and on theoretical model where the hypothalamic disconnectivity determines the activation in the sympathetic autonomic nervous system, leading to heart disorders: high blood pressure, left ventricular hypertrophy and coronary illness.
Identifying the association of psychological risk factors, patients fitting in a model of psychosomatic dominant personality traits, where the main risk factors are represented by inflexibility, guilt and self-accusation feelings, associated with increase of biological indicators proinflammatory factors, endothelial dysfunction and cytokine aggressiveness and neuroimaging indicators frontal, temporal, hippocampal atrophy, ventriculomegaly, cerebellum atrophy.
Changes identified post-mortem in the arterioles from the frontal cortex were found also in the coronary vessels, suggesting a symmetric evolution The highlighted personality factors are responsible for the decrease of adherence and compliance both in the psychiatric and the cardiologic treatment, the patient being exposed to behavioral risks regarding life style and nutrition, factors that increase the risk for acute coronary accident. The psycho-neurobiological intraductal papilloma sonography theoretical models argument the importance of a differentiated and customized approach of the patients with depressive disorder and suicidal ideation, and they can be the base for initiating strategies for prevention of unfavorable evolution and risk of death by MI.
Due to the rich oro-maxillofacial vasculature and the fact that some dental procedures may cause a bleeding, the physician should be able to correlate this risk with the hemorrhagic risk. Dental procedures are a trigger for psychic stress. One of the most important changes in acute stress is in cardiovascular system. In healthy patients, these changes are reversible and have no significant consequences, but in patients with cardiovascular diseases, the response to the catecholamine stress can cause organic lesions resulting in an acute myocardial infarction or stroke.
This review explores in a concise manner the biochemical changes concerning anticoagulation and thrombolytic treatment in dental procedures. This method of treatment was discovered when primitive Chinese people discovered that pain in one part of the body can be alleviated if it stings in a particular area of the body. Acupuncture has achieved blood cancer genetic link a climax in Ming Dynasty A.
Yang Jizhou compiled a book that presents blood cancer genetic link complete and laborious description of the meridians, collaterals, acupuncture points, manipulating methods of acupuncture and their indications. According to the ancient description of the meridians vierme negru în toaletă collaterals and the research on the anatomy of Western medicine, some scholars think the meridians and collaterals are closely related to the blood vessels.
In recent years, many reports have showed that acupuncture has remarkable effect on the pituitary gland and adrenal cortex system, the sympathetic nerve and adrenal medulla system, the pituitary gland and thyroid gland system, the sexual glands, and the posterior pituitary system.
Thus, some researchers put forth the theory of the meridians and collaterals associated with regulatory function of the neurohumoral system, and the action of acupuncture and moxibustion is brought about by the way of the nerves and body fluid. This condition is accompanied by a strong symptomatology, which has induced intense research on this topic. From a morphological point of view, it is represented by the existence of endometrial glands and, sometimes, of the periglandular stroma endometriosis in the structure of the myometrium, at a significant distance from the normal endometrium.
Various inflammatory, vascular and mechanical factors accentuate the symptoms and evolution of this pathology.
Our study included a total number of 32 patients, eight cases for each of the following histopathological subtypes: endometrium - proliferative phase, endometrium - secretory phase, myometrium with endometrial glands adenomyosisand myometrium with hyperplastic transformation of endometrial glands hyperplastic adenomyosisrespectively. We have conducted clinical, morphological and morphopathological studies of the structures in question.
The interesting aspect of this study is the technique of simultaneously labeling of the inflammatory, vascular and epithelial elements. Changes in EpCAM expression are reported in several malignancies, as an early indicator for carcinogenesis.
Our study aimed to evaluate the EpCAM expression in different subtypes of papillary thyroid carcinoma PTCfocusing on its role in the risk stratification of the histological variants and its relationship with the classical clinico-pathological characteristics.
We analyzed 70 selected cases of PTC, divided into low- and high-risk groups, according to histological criteria. MOC expression was assessed at the membrane and cytoplasmic levels, using a semi-quantitative score that allowed the classification in low- and high-score category, respectively.
The relationship between MOC expression and clinico-pathological characteristics was statistically evaluated. We found statistically significant blood cancer genetic link between MOC expression low versus high and the risk groups, tumor size and tumor relapse. The modification of MOC location, with consequent changes in its interactions with other cell-adhesion molecules, is integrated in the carcinogenic mechanism.
Our study demonstrates the large variability of MOC expression in PTC histological variants, and highlights the differences between the low and high MOC expression that could work as a useful tool for the identification of those high-risk PTC cases, with unfavorable clinical outcome.
Aquaporin 1 AQP1 is a membrane protein characteristic to epithelial and endothelial cell of the human body.
Cancer is genetic or not
The Pax family of genes encodes transcription factors with important role in intrauterine development. Connexins are transmembrane proteins found in gap junctions. Materials and Methods: We studied 34 post mortem fetuses of 9 to 24 weeks from the Laboratory of Pathology, Emergency County Hospital of Targu Mures, Romania, using immunohistochemistry. Results: AQP1 expression appeared in the apical and basolateral parts of cells, lining the proximal convoluted tubules and the descending limb of Henle blood cancer genetic link loop, then blood cancer genetic link the tubule pole of Bowman s capsule also.
Nuclear expression of PAX2 was observed in structures developed both from the ureteric bud and the metanephric mesenchyme, and of PAX8 was observed in the proximal convoluted tubule s epithelium, Henle s loop, and collecting ducts.
Cytoplasmic expression of Cx36 was localized to nephrons in different developmental stages, glomerular vessels and collecting ducts, and of Cx43 was localized to the endothelium of glomerular and peritubular vessels, as well as to the epithelium of the proximal tubules.
Discussions and Conclusions: Nephrogenesis begins in the embryonic period, and continues into the fetal period as well. It is regulated by a wide array of markers. The current study supplements literature data regarding immunoexpression of these markers during renal development in the fetal period. It is a medical condition related to the salivary glands, namely a benign blood cancer genetic link tumor which contains an epithelial component and an abundant lymphoid stroma.
It is also named Warthin tumor after Aldred Scott Warthin, the pathologist who described this entity in by observing it in two patients. Warthin tumor is a benign one and ranks secondly in terms of the most common not malignant salivary gland tumor located in the parotid gland. Because of its cystic nature, from the clinical point of view, it appears to be a slow-growing tumor often fluctuant on palpation. In terms of the treatment of choice, complete excision with wide tumor-free margins is preferred.
The aim of the present blood cancer genetic link is to evaluate possible correlations between clinical-pathological features and postoperative complications in a target group made up of 10 patients diagnosed with Warthin tumor of blood cancer genetic link parotid gland admitted for surgery in a period of 21 years and to compare the results with literature. The structures from which these lesions can arise are the conjunctiva, the limbus, and the cornea.
Our study was conducted on a group of seven patients with ocular surface squamous cell carcinoma SCC.
Histopathologically diagnosed SCCs were then assessed as well, moderately and poorly differentiated, depending on which area of differentiation dominated in Hematoxylin-Eosin staining. For the immunohistochemical analysis, the following antibodies markers were used: Ki67, p53 and B-cell lymphoma 2 Bcl-2E-cadherin, and vascular endothelial growth factor VEGF.
Cancer genetic mutation, [Genetic susceptibility to cancer].
Our study group was composed of seven cases of SCCs of the ocular surface. Four of the cases were histopathologically moderately differentiated SCCs of the ocular surface and three were poorly differentiated SCCs. None of the seven patients present human immunodeficiency virus HIV infection. P53 immunostaining was strongly present in our study. Bcl-2 overexpression is not a fact that our study highlights. The expression of Ki67 proliferation marker was low in our study.
E-cadherin expression in our study was positive. Snail, Twist1 and Slug are transcription factors and play a central role in the epithelial-mesenchymal transition EMTwhich is involved in the progression of renal cell carcinoma RCC. In this study, we analyzed the immunoexpression of these transcription factors in 50 cases of ccRCC, in relation to histopathological aggressiveness parameters of the lesions. The results indicated the association of Snail and Twist1 expression with high Fuhrman grade, as well as the association of Slug expression with low Blood cancer genetic link grade.
The immunoexpression of Snail and Twist1 was significantly superior for advanced stages and Slug was overexpressed in early stages of ccRCC. Our study supports the usefulness of the Snail, Twist1 and Slug expression for the appreciation of aggressiveness in ccRCC, the panel being attractive for targeted therapy. A new solution proposed for optimizing cytology-based screening, before seeing the risk associated with minor abnormalities results, is the use of molecular markers.
All patients were referred for colposcopy and biopsy if appreciated as necessary and followed-up at six and 12 months. Serum levels of thyroid hormones and antioxidant profile were measured. Real-time polymerase chain reaction was used to assess gene expression of catalase CAT.
Testing your Genes for Cancer
Liver was histopathologically examined using routine and immunohistochemical techniques. Moreover, there was an intralobular inflammatory reaction associated with significant p Corresponding author: Nasra Naeim Ayoub, MD, PhD; nasraayuob gmail.
It is a multifactorial condition, in whose etiopathogeny there are involved numerous genetic, metabolic and environment factors. In its turn, AH is one of the most important risk factors for heart disease, stroke, heart failure, kidney disease and peripheral vascular diseases. In hypertensive patients, it progresses into the left ventricle hypertrophy, as a result of some major changes of the cardiomyocytes, but also of the extracellular conjunctive matrix ECM.
We evaluated some histopathological and immunohistochemical changes induced by AH on some fragments of myocardium blood cancer genetic link the left ventricle. There was observed an increase of the ECM quantity, manifested by the expansion of the intercellular spaces, fibrillar collagen synthesis and its deposit in the perivascular and interstitial spaces, a significant reduction of the number of microvessels in the myocardium, the alteration of cardiomyocyte larvas de oxyuris vermicularis, by reducing the quantity of desmin and of the intercellular connections, by reducing cluster of differentiation 56 CD56 neural cell adhesion molecule 1 - NCAM1 immunomarker.
From January 1, until December 31,imagistic and histological evaluations were performed in patients aged between one day and 18 years old, who were diagnosed with different soft-tissue vascular anomalies in our Center. From the patients included in the study, Infantile hemangioma was the most frequent type of soft-tissue vascular anomaly Ultrasound US examination is the most used imaging technique due to its wide accessibility and for providing valuable information about the anatomical localization of the lesions, the type of vessels involved, distribution and density of vascularization.
Magnetic resonance imaging MRI can be used for assessing the extent of deep or large lesions, but it usually requires anesthesia.
Computed tomography CT is useful when patients present contraindications to anesthesia and it has the advantage of a shorter image acquisition time. Histological studies have an important role in establishing the diagnosis even for the atypical blood cancer genetic link of soft-tissue vascular anomalies.
Furthermore, the prognosis depends on the histological type. In conclusion, there is a need for collaboration between the clinician, radiologist, pathologist and surgeon in order to establish a precise diagnosis and therapeutic strategy for each patient. Patients, Materials and Methods: fields with different patterns of PA selected from 83 patients with total prostatectomy according to Gleason and Srigley grading systems were selected.
Four serial sections were cut and stained in order to assess the following parameters: tumor grading with Hematoxylin-Eosin H-Etumor cells architecture GO with Gomori technique, tumor stroma architecture TC with Goldner s trichrome, and vascular network VN architecture blood cancer genetic link cluster of differentiation 34 CD34 immunomarker.
Images were binarized with variable user-defined empiric threshold for Goldner s trichrome staining and CD34 immunostaining and k-nearest neighbor approach for GO staining. The FD was computed for each helmintiaza pe apă image using a box-counting algorithm.
The three computed values were used for clustering and classification, k-nearest neighbor proving to be a good choice with a classification papillomavirus vaccin, due to the irregular distribution of cases in different patterns. Values tending to 1 had the meaning of a more Linear type distribution and values tending to 2 had the meaning of a more Area type distribution.
Tumor stroma architecture had almost the same type of distribution - between linear-like and area-like FD cca. VN architecture had a more linear-like type of distribution FD 0.
Conclusions: Tumor cell population is remodeling and adapting TC and VN in the same way its architectural disposal evolves. TC and VN develop independently of each other, the former towards Area type and the latter towards Linear type of architectural disposal as the degree of differentiation is decreasing.
To asses clinicopathological features and human papillomavirus HPV status of penile SCC in men with late circumcision, eight institutions in the country blood cancer genetic link to collaborate and 15 cases of penile SCC were collected from their pathology archives. The presence and genotype of HPV were determined in addition to clinicopathological features of the tumors.
Findings were correlated with disease outcome. The mean age of the patients evaluated was HPV was identified in Cause-specific 1-year and 2-year survivals were As a conclusion, our results suggest an inclination for penile SCC to develop at a later age in a population blood cancer genetic link late circumcision toxine panton valentine the patients from the regions of high penile cancer incidence.
These men seem to have less frequent HPV association and their outcome appears poorer than other populations, although reaching substantial provision is not possible due to our limited case number. Snail is a transcription factor, expressed in cells which have undergone almost complete EMT and have left the tumor, and Twist is considered important in the process of metastasis, both playing a major role in EMT by indirect inhibition of E-cadherin.
The study analyzed the immunoexpression of E-cadherin, Snail and Twist in 46 cases of colonic carcinomas in comparison with some histopathological prognostic factors. The quantification of reactions was done by using a composite score CS resulted from multiplying the percentage of marked cells with the intensity of immunostaining.
The majority of cases were moderately differentiated tumors, corresponded to stage III, with vascular and perineural invasion. All cases presented positive cytoplasmic and nuclear signals for Snail and Twist. The immunostaining for both markers was intense, with the highest values of CS in G2 and G3 advanced, invasive vascular colonic carcinomas, in comparison with G1, early stage lesions.
Cancer is genetic disease -
We found positive significant linear correlation of Snail and Twist expression. The results obtained indicate the implication of Snail and Twist in colonic carcinoma aggressiveness, useful aspect in the oncological evaluation of patients and guided therapy.
Upper lip, in particular, can have a great influence on the aspect of a smile, which is why its proportional length and thickness can improve a lot a persons smile.