F colorectal cancer, Cancerul colorectal

F colorectal cancer


Through the new techniques and establishment of novel protocols, especially in the field of molecular f colorectal cancer, together with the results from f colorectal cancer vitro, in vivo pre­cli­ni­cal and clinical studies carried out on an im­pres­sive number of patients with various pathologies, scien­tists have established ample associations between the microbiome composition and certain cancers or the f colorectal cancer response.

In some types of cancer, the role of microorganisms has been incriminated, which by their presence can activate certain signaling f colorectal cancer or produce some metabolites that ultimately affect the cel­lular functioning. For some microorganisms such as Fu­so­bac­te­rium nucleatum or toxigenic Bacteroides hpv virus symptome mann in colorectal cancer, the possible mechanisms of action have been already described.

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Despite this fact, numerous stu­dies are still needed in order to determine whether bac­te­rial presence triggers the neoplastic process or the gut microbial abundance in affected patients is the result of other changes taking place.

Keywords microbiome, carcinogenesis, diagnosis Rezumat În ultima perioadă, microbiomul a primit tot mai multă aten­ţie, fiind o temă de cercetare frecvent abordată în numeroase studii. Prin noile tehnici şi stabilirea de pro­to­coa­le ino­va­toare, în special în domeniul biologiei mo­le­cu­lare, ală­turi de coroborarea f colorectal cancer cu ob­ser­va­ţii­le pro­ve­nite din studiile preclinice in vitro, in vivo şi clinice efec­tua­te la un număr impresionant de pacienţi cu diverse pa­to­lo­gii, cercetătorii au constatat asocieri între anumite pa­to­lo­gii neoplazice sau modul de răspuns la tratament şi com­po­zi­ţia microbiomului.

f colorectal cancer

În anumite tipuri de cancer a fost in­cri­mi­nat rolul unor microorganisme care prin prezenţa lor pot activa diverse căi de semnalizare sau pot produce me­ta­bo­liţi care în final afectează funcţionarea celulară.

Deşi pentru microorganisme precum Fusobacterium nu­cleatum sau Bacteroides fragilis toxigen în cancerul co­lo­rec­tal au fost descrise posibile mecanisme de acţiune, sunt în con­ti­nuare necesare numeroase studii pentru a sta­bili dacă pre­zenţa acestor bacterii declanşează procesul neo­pla­zic sau abundenţa lor la pacienţii afectaţi este doar re­zul­ta­tul celorlalte modificări care au loc. Cuvinte cheie microbiom cancinogeneză diagnostic Introduction Tissue homeostasis, density, architecture and function can normally be maintained by a balance between cell growth and programmed cell death signals, together f colorectal cancer other cellular control mechanisms 1.

Microorganisms have been proven to forum pentru tratamentul helmintiazei involved in the etiopathogenesis of some neoplasms 2. For example, Helicobacter pylori interacts through the cytotoxin-associated gene A CagA protein with E-cadherin, an intercellular adhesion molecule, leading to the dissociation of b-catenin from E-cadherin and thus to the cytoplasmic and nuclear accumulation of the first.

Moreover, by prolonged activity of the vacuolating cytotoxin protein VacAmany alterations happen at endosomal, mitochondrial, permeability and signaling level 4leading to the impediment of autophagy 3. Autophagy is a degradation process that involves the formation of autophagosomes, which include cytoplasmic components, and subsequently fuse with lysosomes, but due to the signals of mitochondrial destruction, the cell tries to f colorectal cancer damage and triggers apoptosis instead of autophagy 5.

Oncoviruses also present many mechanisms by which they can be involved in carcinogenesis through two main paths: directly by genes insertion or indirectly by sustained inflammation 3.

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For some types of cancers, parasitic etiologies have been suggested: Schistosoma haematobium, Schistosoma japonicum and Schistosoma mansoni through inflammation and oxidative stress; Opistorchis viverrini, Opistorchis felineus and Clonorchis sineses through inflammation, oxidative stress and cell proliferation 6. At the same time, the presence of some parasites seems to have a beneficial, antineoplastic effect: Echinococcus spp.

The microbiota represents all the microorganisms that are physiologically located in and on the surface of the human body, while the microbiome comprises their genetic material 8. In recent years, the f colorectal cancer interest for the microbiota and its implications in various pathologies has been observed through the multitude of studies, publications, but also scientific meetings on this topic. The role of the microbiota has been highlighted in numerous molecular mechanisms of human body development, f colorectal cancer diseases, hypersensitivity pathologies, and in many others, including neoplastic disorders 9.

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The microbiota can contribute to tumor genesis by direct mechanisms, producing toxins and acting on DNA denaturation, or indirectly, by modifying the tumor microenvironment, promoting unrestricted cell proliferation 9.

In both of these mechanisms, it should be taken into account the numerous effects of the microbiota on the immune system 9.

Colorectal carcinoma - causes, symptoms, diagnosis, treatment, pathology

Colorectal cancer A. Microorganisms with procarcinogenic effect F colorectal cancer involvement of microbiota in the carcinogenesis of colon and rectum has been explained through several ways, such as altering cell proliferation, influencing the immune system or metabolizing food factors. Enterotoxigenic Bacteroides fragilis Bacteroides fragilis colonizes between 0.

So far, two strains have been identified: one toxigenic and the other one non-toxigenic The latter strain has beneficial effects in protective mechanisms against cancer 11while the first one, enterotoxigenic B. This toxin promotes the cleavage of E-cadherin and leads to nuclear translocation of b-catenin and c-myc proto-oncogene transcription, resulting in colonic epithelial cells hyperplasia, increased spermine oxidase expression and reactive oxygen species production, which promote cell injury and carcinogenesis 1.

Another toxin-mediated mechanism is achieved with the implication of the immune system: the accumulation of regulatory T lymphocytes in the intestinal lamina propria, the suppression of mucosal immune response by T helper-1 lymphocytes, the increased interleukin IL secretion, ultimately leading to tumor genesis.

Purpose: The phytochemical profile and anticancer potential of three Ajuga sp. Materials and Methods: The phytochemicals were extracted from the aerial parts of Ajuga sp. The phytochemical profile was also evaluated by principal component analysis in connection with antitumor efficacy of extracts. Western Blot with regard to f colorectal cancer protein NF-κB nuclear factor kappa-light-chain-enhancer of activated B cells p65 subunit expression in cell lysates was performed. Enzymatic and non-enzymatic antioxidant capability was assessed by measuring catalase activity and by evaluating the total antioxidant capacity TAC of treated cells.

Increased MDSC can lead to increase in nitric oxide NO f colorectal cancer arginase 1 levels, thus being responsible for inhibiting T lymphocytes and avoiding the antitumor immune response According to the alpha-bug hypothesis, ETBF remodels the colonic microbiota and cooperates with environmental factors and host genetics to induce colon cancer 1.

Fusobacterium nucleatum Fusobacterium nucleatum is an opportunistic anaerobic commensal of the oral cavity, which may be involved in the production of periodontal disease, but it can also cause diseases in other areas of the body, such as intrauterine infections with major pregnancy complications Recently, F. One of the virulence factors expressed on its surface is FadA, which exists in two forms: the intact form pre-FadAanchored in the membrane, and the secreted mature FadA mFadA.

Only the pairing of the two forms represents an active complex the pre-FadA-mFadA complexwhich has the ability to attach to the endothelial cells through E-cadherin and activate signaling pathways through b-catenin This process leads to increased expression of transcription factors, oncogenes, inflammatory genes and stimulates the development of cancer cells Fusobacterium varum may also act through the same mechanism Several mechanisms have been proposed regarding the involvement of F.

Cancerul colo-rectal incipient – epidemiologie, diagnostic

This protein appears to be involved in the adhesion of tumor cells, which overexpress Gal-GalNAc molecules This process is followed by the interaction between F. When a Wnt ligand binds to the transmembrane domain of Frizzled proteins family of G protein-coupled receptor f colorectal cancer and its coreceptors, low-density lipoprotein receptor related protein 5 or 6 LRPthey form a complex together with the recruitment of the Dishevelled protein, which results in the phosphorylation and activation of LRP6.

Moreover, in the infection with F. In addition to this, studies on F.

Implicaţiile microbiomului în iniţierea şi promovarea carcinogenezei

Another possible involved mechanism is inflammation, with high levels of TNF-a and IL being observed in people with concurrent colonic adenomas and F. In those with colon cancer, increased levels of IL-6 and IL-8 have been noticed in the presence of F. The presence of this bacterium has been associated with poor survival in patients with colon cancer and also with resistance to chemotherapy Escherichia coli Escherichia coli is a widespread Gram-negative bacterium, also part of the human gut microbiota.

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It is divi­ded into 5 phylogenetic groups, but the most commonly involved in human pathologies is the one belonging to B2 group The mechanism by which this leads to the development of colon cancer is not exactly known, but there are two main pathways currently under investigation: one indirectly by inflammation and the other one directly through molecular mechanisms For example, both adherent invasive E.

Colibactin induces apoptosis of immune cells and chromosomal instability with DNA damage in the epithelial cells, leading to their senescence secretory phenotype of senescent cells Although the cells are no longer dividing, they may secrete growth factors which allow tumor development EspF may decrease the level of repair proteins MLH1 and MLH2 11 and it may also contribute to metastasis process by f colorectal cancer on the intercellular tight junction proteins occludin and claudin-1 Other proteins produced by E.

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Salmonella spp. Salmonella enterica comprises several serotypes, such as Salmonella typhi, Salmonella paratyphi, Salmonella enteritidis and Salmonella typhimurium In recent years, cancers of the colon, gall bladder and other cancers of the gastrointestinal tract have been correlated with infections caused f colorectal cancer S.

The mechanism of cancer transformation can also be direct and indirect, as in the case of other pathogens described There are two identified toxins responsible for these mechanisms: typhoid toxin a cyclomodulin similar to the one produced by E.

Typhoid toxin can increase cell survival and promote intestinal dysbiosis AvrA has been identified in the stool samples from colon cancer patients f colorectal cancer several possible mechanisms of action have been suggested, including the inhibition of NF-kB signaling pathway, inhibition of IL, INF-g, TNF-a secretion, IL-6 transcription and stimulation of IL transcription By its activity of acetyl transferase, AvrA can affect p53 activity, decreasing apoptosis It has been observed that the higher incidence of gallbladder cancer in some geographical areas corresponds to the increased incidence of Salmonella spp.

Enterococcus faecalis By producing increased amounts of superoxide at the luminal level of the colonic mucosa, Enterococcus faecalis can lead to DNA damage, point mutations 2chromosome instability and cellular aneuploidy 1. In vitro studies have proven that E. However, some studies even suggest a possible protective role of E.

Streptococcus gallolyticus Streptococcus gallolyticus formerly known as S.

  • The aim of this study was to evaluate the use of colonoscopy as the screening test in asymptomatic first-degree relatives of CRC patients.
  • Functia acestor gene poate fi perturbata de deletii, insertii sau rearanjamente genomice mari.
  • Through the new techniques and establishment of novel protocols, especially in the field of molecular bio­lo­gy, together with the results from in vitro, in vivo pre­cli­ni­cal and clinical studies carried out on an im­pres­sive number of patients with various pathologies, scien­tists have established ample associations between the microbiome composition and certain cancers or the treat­ment response.

Although frequently reported, the mechanism of action is not yet fully elucidated, but carcinogenic effect is most likely produced by inflammatory effects In vitro studies have shown that mucosal exposure to this bacterium leads to increased IL-1 16but also IL-8, the latter being involved in carcinogenesis processes by increasing oxidative stress, promoting angiogenesis, tumor proliferation and overexpression of COX-2 Another recent theory mentions the ability of S.

In this case, it acts by activating the Wnt pathway, then decreasing Slc10A2 protein production Solute Carrier Family 10 Member 2, a bile acid transporterwhich leads to the accumulation of bile acids. Moreover, bacteriocine production is activated, allowing S. Clostridium septicum Due to its ability to produce alpha-toxin that binds to GPI glycosylphosphatidylinositol receptors on the cell surface, including folate f colorectal cancer, Clostridium septicum f colorectal cancer been associated in some studies with carcinogenesis Microorganisms with possible protective effect Some studies have pointed out that certain bacteria may play a protective role in neoplastic processes through numerous mechanisms, including the production of short-chain fatty acids 1.

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They are produced in the intestine by microbial fermentation of the dietary fibres, representing the primary energy source for the colon epithelial cells, as opposed to the cancer cells, which are based on carbon source metabolism, especially on glucose 1. Eubacterium rectale and Faecalibacterium prausnitzii may be nu un medicament pentru viermi in the butyrate production, having an anti-inflammatory role by inducing IL expression Furthermore, the intracellular increased level of butyrate concentration may act as an inhibitor of histone deacetylation, which stimulates apoptosis and inhibits cell proliferation 1.

Through their components, probiotics may have implications in modulating the immune system. For example, the lipopolysaccharide f colorectal cancer the bacterial membrane of Gram-negative bacteria may activate the TLR4 surface receptor, which stimulates f colorectal cancer T-cell-mediated immune response against cancer cells Cancerul la unghii, Bacteroides thetaiotamicron and non-toxigenic B.

Lactobacillus casei BL23 has immunomodulatory effects by lowering IL and also antiproliferative influence by increasing caspase-7 and caspase-9 In addition to this, it produces ferrichrome, a tumour-suppressive molecule, by which it can trigger apoptosis in tumor cells Clostridium nexile f colorectal cancer contribute to the anticancer effects of Pseudomonas aeruginosa Monophosphoryl lipid A, a modified synthetic form of lipid A, derivatived from Salmonella enterica Salmonella minnesotahas been used as an adjuvant in anticancer vaccines The composition of gut microbiota in oncology One of the studies that compared the composition of the microbiota of healthy people with the one of those with different types of cancers identified the following five most frequent phyla: Firmicutes, Bacteroidetes, Actinobacteria, Proteobacteria and Verrucomicrobia The abundance of Firmicutes was high in all groups, but this bacterium was predominant in healthy individuals, those with hyperplastic polips and low-risk or high-risk adenomas, compared with adenocarcinoma group, where it was found in a lower proportion Bacteroidetes was lower in healthy people and in those with low-risk lesions, but more abundent in people with adenocarcinoma Actinobacteria and Verrucomicrobia were very low in f colorectal cancer adenocarcinoma group, but much more frequent in the others Firmicutes, Bacteroidetes, Actinobacteria and Proteobacteria predominated in healthy people.

A decrease in Firmicutes and Actinobacteria, together with increased Proteobacteria, has been observed in patients with adenocarcinoma Oropharyngeal cancer Studies investigating the oral microbiome, performed on people with preneoplastic or neoplastic lesions, showed a decrease of the Firmicutes and Actinobacteria phyla In tests using saliva specimens, a decrease of the microbial diversity and abundance has been observed, together with the increase of Lactobacillus representation and total loss of various bacterial genera such as Haemophilus spp.

  • Source: Acta Medica Transilvanica.
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  • Post-surgery morbidity and mortality in colorectal cancer in elderly subjects. | Semantic Scholar
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Esophageal cancer The mechanism of action of the microbiome in the etiopathogenesis of esophageal cancer is not confirmed, but there f colorectal cancer several hypotheses available and it seems that inflammation may be the basis of carcinogenesis Usually, people without esophageal diseases have a type I microbiota at this level, which is composed predominantly of Gram-positive bacteria. In cancer patients, there has been observed a replacement of the normal bacterial populations with the Gram-negative ones type II microbiota The interaction of the microbial molecules with TLR4 activates the NF-kB pathway involved in inflammation-associated carcinogenesis In addition to these mechanisms, there are also toxins produced by some bacteria, which can affect DNA and therefore promote carcinogenesis Liver cancer Dysbiosis and increased intestinal wall permeability may amplify the risk of liver cancer by several mechanisms, including by release of deoxycholic acid caused by the modified microbiota or by liver exposure to other f colorectal cancer gut-derived microbiota associated molecular patternssuch as lipopolysaccharide from the Gram-negative bacteria.

These bacteria may play a role in inflammation, fibrosis, proliferation and activation of anti-apoptotic signaling pathways One of the mechanisms may be through the interaction of lipopolysaccharide with TLR, which results in the inhibition of hepatocyte apoptosis by the NF-kB pathway Pancreatic cancer The identification of Haemophilus spp.

Porphyromonas gingivalis found also in the oral cavity is considered to be a risk factor for pancreatic neoplasm, being involved in carcinogenesis, most likely through the secretion of an enzyme peptidyl-arginine deiminasewhich can lead to p53 and K-ras mutations More­over, bacterial DNA of microorganisms present in the oral cavity has been identified in the pancreatic cysts formed by mucus produced in a form of pancreatic cancer intraductal papillary mucinous neoplasm Prostate cancer In a study that included men with suspected prostate neoplasm, the investigators performed urine culture tests prior to prostate needle biopsies and observed an association between the ce paraziți trăiesc of cancer cells at this level and the identification of a group of bacteria most commonly involved in urogenital infections: Streptococcus anginosus, Anaerococcus lactolyticus, Anaerococcus obesiensis, Actinobaculum schaalii, Varibaculum cambriense and Propionimicrobium lymphophilum Other studies have highlighted an increase in Bacteroides and Streptococcus spp.

The mechanism is not yet fully elucidated, but appears to be due to inflammation and the production of reactive oxygen species that can affect DNA, leading to genetic instability The direct ability of bacteria to produce cancerous lesions has not been described, but in the f colorectal cancer of other factors, such as physical injury through corpora amylacea or urinary reflux, bacteria may invade the organ and find favourable environment for multiplication, with the well-known inflammatory consequences Cutibacterium acnes seems to be involved also in prostate cancer, not only in acne, being identified in prostate biopsy samples.

However, the one isolated from the prostate proved to have different characteristics than the cutaneous one These strains are able to invade host cells and induce COX-2 signaling pathway, after being injected in the prostate of laboratory f colorectal cancer, leading to tumor formation at this level, as it was shown in a murine study Breast cancer The breast microbiota can be dominated by Proteobacteria and Firmicutes Regarding the difference between healthy individuals and breast cancer patients, in the first group the predominance of Enterobacteriacae, Bacillus spp.

The possible mechanisms include DNA damage, but also the production of enzymes. One example is Bacillus cereus, which can produce various enzymes that metabolize progesterone and testosterone At the same time, there have been identified some microorganisms which, by their ability to modify the structure of certain hormones, can f colorectal cancer the risk of breast cancer